Quan Zhang

Dr. Zhang received his Ph.D. in Biomedical Engineering at Xi’an Jiaotong University, China in 1997, and completed his post-doctoral fellowships at the Department of Radiology at the University of Pennsylvania and at Massachusetts General Hospital. Dr. Zhang received his Harvard Medical School Instructor appointment in 2004, and joined the Center for Engineering in Medicine in 2006.

Dr. Zhang has extensive experience in biomedical optics, electronics and imaging science and technology. He has performed research on optical breast cancer detection, long-term ambulatory monitoring for the diagnosis of acid reflux and non-cardiac chest pain. Currently Dr. Zhang is especially interested in the interactions between cells and lasers, and the in vivo monitoring of tissue growth. His work focuses on techniques for triggering cells to repair themselves, and the selective targeting of the retinal pigment epithelium for the treatment of macular degeneration diseases. Dr. Zhang is also interested and involved in the noninvasive monitoring of brain pathology such as hematoma and ischemia, and prevention of stroke using near-infrared spectroscopy and diffuse optical imaging.

Selected Peer-Reviewed Publications

Song Q, Uygun B, Banerjee I, Nahmias Y, Zhang Q, Berthiaume F, Latina M, Yarmush ML, Low power laser irradiation stimulates the proliferation of adult human Retinal Pigment Epithelial cells in culture, Cellular and Molecular Bioengineering, 2009; 2(1): 87-103

Zhang Q, Strangman GE, Ganis G, Adaptive filtering to reduce global interference in NIRS-measured brain activation: How well and when does it work? NeuroImage, 2009; 45(3):788-794

Strangman G,  Zhang Q, Zeffiro T, Near-Infrared Neuroimaging with NinPy, Frontiers in Neuroinformatics, 2009; 3(article 12): 1-13

Fang Q, Carp SA, Selb J, Boverman G, Zhang Q,  Kopans DB, Moore RH, Miller EL, Brooks DH, Boas DA. Combined optical imaging and mammography of the healthy breast: optical contrast derived from breast structure and compression, IEEE Trans Medical Imaging, 2009; 28(1):30-42

Zhang Q, Cole AJ, Cash SS, Medvedev AV, Strangman GE, Simultaneous EEG and diffuse optical imaging to improve noninvasive localization of epilepsy, in Schachter SC, Guttag J, Schiff S, Schomer DL, Summit Contributors, Advances in the Application of Technology to Epilepsy: The CIMIT/NIO Epilepsy Innovation Summit, Epilepsy & Behavior, 2009(16), 22-23

Zhang Q, Brown EN, Strangman GE. Adaptive filtering for global interference cancellation and real time recovery of evoked brain activity: a Monte Carlo simulation study. J Biomedical Optics, 2007; 12: 044014.

Zhang Q, Brown EN, Strangman GE. Adaptive filtering to reduce global interference in evoked brain activity detection: a human subject case study. J Biomedical Optics, 2007; 12: 064009.

Zhang Q, Brukilacchio TJ, Li A, Stott JJ, Chaves T, Wu T, Moore RH, Kopans DB, Boas DA. Co-registered Tomographic X-ray and Optical Breast Imaging. J Biomedical Optics, 2005; 10: 024033.

Li A, Zhang Q, Culver JP, Miller EL, D.A. Boas, Reconstructing chromophore concentration images directly by continuous-wave diffuse optical tomography, Optics Letters, 2004; 29: 256-258.

Zhang Q, Ma HY, Nioka S, Chance B. Study of near infrared technology for intracranial hematoma detection, J Biomedical Optics, 2000; 5: 206-213.

Patents

Zhang Q, Strangman G. Electro-optical system, apparatus, and method for ambulatory monitoring, (Pending), 2005, USA

Boas DA, Zhang Q, Li A. Systems and method for generating an image, United States Patent No. 7333647

Boas DA, Zhang Q, Li A. Systems and method for generating an image, European patent No. 1495466

Zhang Q, Zheng C, Zhang S. Multi-point pH Probe with Internal Reference: No.97 2 08372.3, China

Zhang Q, Zheng C, Zhang S. Multi-point pH Probe with External Reference: No.97 2 08374.X, China