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Yaakov (Koby) Nahmias

Dr. Nahmias received his B.Sc. in Chemical Engineering from the Technion - Israel Institute of Technology, Magna Cum Laude, and his Ph.D. in Biomedical Engineering at the University of Minnesota.

Koby became a faculty member of the CEM at Massachusetts General Hospital in 2006, and an associate member of the Center for Bioengineering in the Service of Humanity at the Hebrew University of Jerusalem in 2009.

His work focuses on the study and development of microscale liver tissues using microfabrication and cell patterning. The ultimate goal is to develop advanced liver tissues that will display differentiated function and an in-vivo-like response to challenges such as inflammation and viral infection. He is especially interested in the interactions between endothelial cells and hepatocytes, which have been shown to be important for the development of the mature liver, the differentiation of stem cells along the hepatic linage, and Hepatitis C virus infection. His recent work has been featured by JAMA, PNAS, and the Faculty of !0,000 Medicine. Dr. Nahmias is the recipient of an NIH Mentored Scientist Career Development Award (K01).

Recent Publications

S. Kidambi, R. Yarmush, E. Novik, P.B. Chao, M.L. Yarmush, Y. Nahmias, Oxygen-mediated enhancement of metabolism, functional polarization, gene expression, and drug clearance in co-cultures of primary hepatocytes, Proc Natl Acad Sci USA 106(37):15714-9 (2009)

R. Jindal, Y. Nahmias, A. W. Tilles, F. Berthiaume, M.L. Yarmush. Amino acid mediated heterotypic interaction govern performance of hepatic tissue model. FASEB J. 23(7):2288-98 (2009).

H. Tolboom, P. Roos, M.L. Izamis, J. Milwid, K. Uygun, Y. Nahmias, F. Berthiaume, M.L. Yarmush, Recovery of warm ischemic livers by ex vivo normothermic perfusion in a rat model of liver transplantation. Transplantation. 87(2):170-7 (2009)

S. Kidambi, J. Yarmush, W. Fong, S. Kamath, J. SchianodiCola, Y. Nahmias, Propofol induces a Dose-Dependent Alteration in the Expression of c-Fos and Egr-1 in Neuronal Cells, Neuroreport 6;20(7):657-62 (2009)

O. Benny, O. Fainaru, A. Adini, F. Cassiola, L. Bazinet, I. Adini, E. Pravda, Y. Nahmias, S. Koirala, G. Corfas, R. J. D'Amato, J. Folkman, An orally delivered small-molecule formulation with antiangiogenic and anticancer activity, Nature Biotechnology. 26(7):799-807 (2008)

Y. Nahmias, J. Goldwasser, M. Casali, D. van Poll, T. Wakita, R. T. Chung,  M. L. Yarmush, ApoB dependent HCV Secretion is Inhibited by the Grapefruit Flavonoid Naringenin, Hepatology 47(5):1437-45 (2008)

Edited Books

Microdevices in Biology and Medicine (Methods in Bioengineering Series), Y. Nahmias, SN. Bhatia, Editors, Artech House, Aug (2009)


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