My major research interests lie in two areas. The first area focuses on the dynamic changes in the bone marrow stem cell populations leading to immunosuppression after severe burn injury and severe trauma.
The second area focuses on the development of methods to enhance the metabolic functions of liver cells in culture for the purpose of bioartificial liver development. I also collaborate with other investigators in studies on the mechanisms of muscle wasting and metabolic derangements that occur in the body after severe injury.
Berthiaume F, Aparicio CL, Eungdamrong J, Yarmush ML. Age- and disease-related decline in immune function: an opportunity for “thymus-boosting” therapies. Tissue Eng 1999; 5: 499-514.
Baskaran H, Yarmush ML, Berthiaume F. Dynamics of tissue neutrophil sequestration after cutaneous burns in rats. J Surg Res 2000; 93: 88-96.
Berthiaume F, MacDonald AM, Kang YH, Yarmush ML. Control analysis of mitochondrial metabolism in intact hepatocytes: effect of interleukin-1b and interleukin-6. Metabol Eng 2003.
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