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The projects in this thrust area are primarily the development of a bioartificial liver device and the next generation of bioartificial skin.
The liver device work revolves around a flat-plate, grooved, microfabricated hepatocyte bioreactor that overcomes the major transport-related shortcomings of the current systems, which use hollow fiber-based reactors. Recent scale-up and in vivo testing of this design have yielded dramatic, positive results.
In the bioartificial skin area, we have developed a number genetically modified skin grafts for local delivery of growth factors such as PDGF, IGF-1, and KGF to promote and modulate the wound healing response in cases of severe burn injury or skin ulcers.
Home > Research Intro > Tissue Engineering
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