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Three projects currently comprise this thrust area. In the first, we seek to develop new classes of antibodies that are environmentally responsive. In our most recent work, we utilized elastin peptide linkers (the flexibility of which is temperature dependent) to engineer single-chain antibody binding fragments that are thermally responsive.

In the second project, we are investigating classical conditioning strategies that will boost a patient’s immune system so that immune readiness or response can be upregulated by an appropriate conditioned stimulus.

In the third project, we are working on developing effective cancer vaccines that are universal and not patient-specific.



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