The focus of the “Global Health” research group is to design novel diagnostic tools for AIDS, tuberculosis and malaria, the three major diseases affecting disproportionately high number of poor people. Although several diagnostic tools exist today in the developed world for each of the three diseases, these tools are either too expensive or require an efficient infrastructure which is not available in resource poor settings. We have invested significant effort in the development of tools for AIDS diagnostic based on CD4 T lymphocyte cell count. Specifically, we developed microfluidic devices that use a cell affinity chromatography approach under differential shear flow to specifically isolate CD4+ T lymphocytes with high efficiency directly from 10 microlitres of unprocessed, unlabeled whole blood. We are currently investigating similar approaches for other in the area or malaria and tuberculosis point-of-care devices for diagnostic.