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We are currently working toward identifying the rate-limiting steps in the retroviral transfection process with an eye toward making large-scale vector manufacturing both efficient and cost-effective.

Most recently we have focused on understanding the mechanism of retrovirus decay, which appears to be due to retroviral RNA degradation. We are currently developing several strategies to efficiently block or overcome this degradation.

In a second related effort, we are using genetic transfer techniques to overexpress various growth factors in skin cells with an eye toward understanding the role of these growth factors in the wound healing process.



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