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CEM researchers are using conventional genomics and proteomics technologies to document the liver’s gene and protein expression response to inflammation through in vitro and in vivo studies.

Studies such as these, in combination with parallel metabolic profiling studies, are crucial for understanding the hypermetabolic course taken by injured patients, which can vary dramatically, leading to recovery, chronic illness or death.

We are also developing a living cell array, a novel and transformative functional genomics tool for the simultaneous measurement of temporal expression profiles of multiple genes. Information from this new device will be used to predict the molecular events that determine a cell’s progression to recovery or failure in response to stress.



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