ANIMAL MODELS

In Vivo Geometric Specification of the Ovine Right Ventricular Outflow Tract
Danielle Gottlieb, Aaron Cois, Andrew J. Powell, Arthur Nedder, David A. Annese, George Stetten, Michael Sacks, John E. Mayer, Jr.
Children’s Hospital Boston, Massachusetts, Departments of Cardiology and Cardiovascular Surgery; University of Pittsburgh Department of Bioengineering, Pittsburgh, Pennsylvania

In Vivo Vasculogenic Potential of Blood-Derived Endothelial Progenitor Cells: Potential Applications for Tissue Engineering
Juan M Melero-Martin, Zia A Khan, Joyce Bischoff
Vascular Biology Program, Department of Surgery, Children’s Hospital Boston, 300 Longwood Ave, Boston, MA 02115, USA

ST/HR Hysteresis as a Predictor of Coronary Artery Disease Due to Graded Flow Reduction in Porcine Heart
Vivek Varadarajan
Mediwave Star Technology Inc.Greensboro, NC-27405

Autologous Myotissue Implant into Myocardial Infarct Scar Decreases Infarct Size and Improves Left Ventricular Function: Preliminary Preclinical Results From a “Proof Of Concept” Study in a Porcine Model of Myocardial Infarction
Joanna J. Wykrzykowska, Seung U. Lee, Shigetoshi Mieno, Neel Sodha, Richard Clements ,Laurel Donnell-Fink, Munir Boodhwani, Evan Appelbaum, Frank W. Sellke2, Cesario Bianchi, Joseph P. Carrozza, C. Michael Gibson, Roger J. Laham
Cardiology Division, Cardiovascular Surgery of the Beth Israel Deaconess Medical Center, Harvard Medical School, Boston MA 02215

BIOMEDICAL SENSORS AND INSTRUMENTATION

Yield Stress Measurement of Blood
Daniel De Kee, Kyle Frederic
Department of Chemical and Biomolecular Engineering and Tulane Institute for Macromolecular Engineering and Science (TIMES)
Tulane University,New Orleans, LA 70118

Analysis of Thin Films for Bioengineering Applications by Quartz Crystal Microbalance with Dissipation Monitoring (QCM-D)
Stephen L. Hussey
Q-Sense Inc. 808 Landmark Drive, Suite 124, Glen Burnie, MD 21061

Tools for Monitoring of Bioprocesses and Cell Culture
Yordan Kostov, Xudong Ge, Govind Rao
Center for Advanced Sensor Technology, University of Maryland, Baltimore County Dept. Chemical & Biochemical Engineering, TRC building, rm. 230
5200 Westland blvd, Baltimore MD, 21227

Miniaturizing Oxygen Sensor Technology for Tissue Engineering Applications
Miguel A. Acosta, Yordan Kostov, Jennie B. Leach
University of Maryland – Baltimore County
Department of Chemical and Biochemical Engineering

Enhancing the Sensitivity and Dynamic Range of TSMs Operating under Highly Viscous Medium
Francois M. M. A., Desa J., Ergezen E., Pourrezaei K., Lec R.
School of Electrical and Computer Engineering, Drexel University, Philadelphia PA
School of Biomedical Engineering, Science and Health Systems, Drexel University,
Philadelphia, PA

An Avalanche Photodiode Array for Polychromatic Flow Cytometry using Visible and Near Infrared Fluorescence
W. G. Lawrence, G. Varadi, R. Farrell, G. Entine, E. Podniesinski, P. K. Wallace
Radiation Monitoring Devices, 44 Hunt St., Watertown MA 02472;
Roswell Park Cancer Institute, Elm and Carlton Streets, Buffalo NY 14263

Metabolic and Morphological Assessment of Normal and HPV Transfected Engineered Tissues Using Multi-Photon Fluorescence
Jonathan M. Levitt, Margaret McLauglin-Drubin, Karl Munger, Irene Georgakoudi
Tufts University, Department of Biomedical Engineering, Medford, Mass
Department of Medicine, Brigham & Women’s Hospital, Harvard Medical School, Boston, Mass

Design of a Handheld Electrical Impedance Probe for the Assessment of Neuromuscular Disease
O.T. Ogunnika, M. Scharfstein, J.L. Dawson, S.B. Rutkove
Department of Electrical Engineering and Computer Science, Massachusetts Institute of Technology, Cambridge, MA
Department of Neurology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA

Optimization of Desiccation Preservation of Mammalian Cells
Ranjan Sitaula, James Green, Bingyan Chen, Sankha Bhowmick, Alex J. Fowler, Mehmet Toner
Biomedical Engineering and Biotechnology Program, University of Massachusetts Dartmouth
Mechanical Engineering Department, University of Massachusetts Dartmouth
Center for Engineering in Medicine, Massachusetts General Hospital, Harvard Medical School and Shriners Hospital for Children, Boston, MA

The Effect of Acute Citalopram Infusion on the BOLD Signal During a Sensorimotor Task in Healthy Volunteers
Venkatraman VK, Aizenstein HJ, Bigos KL, Hariri AR, Bies RR, Pollock BG
Department of Bioengineering, Department of Pharmaceutical Sciences, 3Department of Psychiatry, University of Pittsburgh, PA, USA

Towards Long-Term Ambulatory Neuromonitoring
Quan Zhang, Christina Supelana, Gary E. Strangman
Massachusetts General Hospital, Radiology/NMR Ctr-CNY
149 13th Street, Charlestown, MA 02129

CELL SIGNALING AND MODELING

BioNetGen at the Virtual Cell: Extending Biomolecular Interactions to account for Combinatorial Complexity
Michael L. Blinov, James C. Schaff, Anuradha Lakshminarayana, Fei Gao, Leslie M. Loew
Center for Cell Analysis and Modelling, University of Connecticut Health Center
Farmington, CT 06030, USA

A 3d Model of Calcium Signaling in Cerebellar Purkinje Cells
Sherry-Ann Brown, James Watras, Frank Morgan, Leslie Loew
National Resource for Cell Analysis & Modeling, UCHC

JNK Binds to and Regulates Adherens Junctions
Piyush Koria, Meng Horng Lee and Stelios T. Andreadis
Bioengineering Laboratory, Department of Chemical and Biological Engineering,
University at Buffalo, The State University of New York, Buffalo, New York

Development of a Database of a Library of Transcriptionally Active Target Sites in Biologically Stressed Plants: A Potential Tool for Identifying Novel Transcriptional Regulators Involved in Defense Mechanism
Vibha Sandeep Rani
Jaypee Institute of Information Technology University, India

Kinetic Modeling using BioPAX Ontology
Oliver Ruebenacker, James C. Schaff, Ion I. Moraru, Michael L. Blinov*
Center for Cell Analysis and Modeling, University of Connecticut Health Center, Farmington, CT, USA

Selective Photocoagulation Induced Bio-Stimulation Effects in Pigmented RPE Cells and Related Biological Mechanisms
Qing Song, Rongjun Zuo, Zak Megeed, Francois Berthiaume, Yaakov Nahmias, Mark Latina, Martin L. Yarmush
Center for Engineering in Medicine/Surgical Services, Massachusetts General Hospital, Harvard Medical School and Shriners Burns Hospital

What Determines the Persistence of Intracellular Growth Factor Signaling?
Rami Tzafriri and Elazer Edelman
Harvard-MIT Biomedical Engineering Center
Division of Health Sciences and Technology, MIT, Cambridge, MA

EXTRACELLULAR MATRIX/SCAFFOLDS

Non-Viral Transfer of GDNF Plasmid DNA to Mesenchymal Stem Cells via Collagen Scaffolds
Catherine Bolliet, Martha C. Bohn, Myron Spector
Massachusetts Institute of Technology, Cambridge, MA, USA
VA Boston Healthcare System, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA, USA
Children's Memorial Research Center, Northwestern University, Chicago, IL, USA

Improving Bioengineered Skin Substitutes: Controlling the Extracellular Matrix to Direct Epithelialization
K.A. Bush, P. Driscoll, E. Soto, W.G. McGimpsey, G.D. Pins
Worcester Polytechnic Institute, Biomedical Engineering, Worcester, MA
University of Massachusetts Medical School, Graduate School of Biomedical Sciences, Worcester, MA
Worcester Polytechnic Institute, Chemistry & Biochemistry, Worcester, MA
Center for Molecular Engineering, Bioengineering Institute, Worcester, MA

Effects of Scaffold Architecture in Modulating Cellular Functions
Ming Chen, Prabir K. Patra, Steven B.Warner, Sankha Bhowmick
Biomedical Engineering and Biotechnology Program, Department of Materials and Textile Sciences, Department of Mechanical Engineering, University of Massachusetts - Dartmouth, N. Dartmouth, MA 02747

3D Microfabrication of Tissue Engineering Scaffolds via Multiphoton Excitation
Larry Cunningham, Katie Bush, Matthew Veilleux, George Pins, Paul J. Campagnola*
University of Connecticut Health Center, Center for Cell Analysis and Modeling, Department of Cell Biology, Farmington, CT
Worcester Polytechnic Institute, Department of Biomedical Engineering, Worcester, MA

An Oscillatory, Perfused Bioreactor for Cell and Tissue Culture
Moretti, M.G., Cheng, M.Y., Nichol, J.W., Freed, L.E.
Harvard-MIT Division of Health Sciences & Technology, Cambridge, MA
Department of Structural Engineering, LaBS, Politecnico di Milano, Italy
IRCCS Istituto Ortopedico Galeazzi, Milano, Italy

Differential Effect of Sequentially Seeding of Mesenchymal Stem Cells and Endothelial Progenitor Cells vs. Seeding Endothelial Progenitor Cells alone on Cellularity and Cell phenotypes
Virna L. Sales, John E. Mayer, Jr.
Department of Cardiac Surgery, Children’s Hospital Boston, Harvard
Medical School, Boston, MA, 02115, USA 617- 919- 2922

First Direct Evidence that Retrovirally Labeled Endothelial Progenitor and Mesenchymal Stem Cells Persist and Contribute to a Functional Tissue Engineered Pulmonary Artery Augmentation Patches In Vivo
Virna L. Sales, Bret A. Mettler, John E. Mayer, Jr.
Department of Cardiac Surgery, Children’s Hospital Boston, Harvard
Medical School, Boston, MA, 02115, USA 617- 919- 2922

IMAGING/MICROSCOPY

Quantification of Density and Alignment of Type I Collagen Fibrils within Cellular Gels using Second Harmonic Generation
Christopher Bayan, David Kaplan, Irene Georgakoudi
Tufts University

Advances in In Vivo Imaging and Flow Cytometry for Biological Studies
C. P. Lin et al.
Advanced Microscopy Group, Wellman Center for Photomedicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA.

Thermographic Assessment of Cold Stimulation on Autonomic Vascular Reactions
Shay Edwards
2554 Corydon Ave, Norco CA 92860 Phone: 951-735-9003

Imaging of Targeted Drug Delivery to Tumors using Contrast Enhanced MRI
V. Kaimal, SK. Holland, Z. Chu, DD. Richardson, X. Qi
Biomedical Engineering, University of Cincinnati, Cincinnati, OH, United States,
Imaging Research Center, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, United States, Human Genetics, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, United States, Chemistry, University of Cincinnati, Cincinnati, OH, United States
.

Virtual Frap Tool: Modeling Frap Experiments
James Schaff, Frank Morgan, Anuradha Lakshminarayana, Fei Gao, Ion Moraru, Leslie Loew
Center for Cell Analysis and Modeling, University of Connecticut Health Center

Label-Free Imaging of Complex Biological Samples by
Time-Resolved Broadband CARS Microscopy
Young Jong Lee, Marcus T. Cicerone
Polymers Division, National Institute of Standards and Technology, Gaithersburg, MD 20899, USA

A Fast and Reliable Method in Characterizing Bacterial Adhesion on Host Cells and Biomaterials
Yatao Liu, Joshua Strauss, Paola A. Pinzon-Arango, Terri A. Camesano
Department of Chemical Engineering, Department of Biomedical Engineering,
Worcester Polytechnic Institute, Worcester, MA 01609, USA

Second Harmonic Generation Imaging Microscopy of Diseased States
Oleg Nadiarnykh, Ronald LaComb, Molly Brewer, Paul J. Campagnola
University of Connecticut Health Center, Center for Cell Analysis and Modeling, Department of Cell Biology, Farmington, CT
University of Connecticut Health Center, Neag Cancer Center, Department of Obstetrics and Gynecology, Farmington, CT

Cranberry’s Action against Escherichia coli and Urinary Tract Infections: Investigating Adhesion and Physicochemical Changes in Bacteria
Paola A. Pinzon-Arango, Yatao Liu, Terri A. Camesano
Worcester Polytechnic Institute, Worcester, MA 01609

Phase Preserving Method for Information Compression Useful in Functional Image Reconstruction with Applications in Clinical Image Databases
Anuj Sharma
Department of Biomedical Engineering, Manipal Institute of Technology, Manipal University, India

Electric Field Effects on Mesenchymal Stem Cells
Marie Tupaj, David Kaplan & Irene Georgakoudi
Department of Biomedical Engineering, Tufts University

MICROFABRICATION

Organotypic Neural Circuit on Microfabricated Substrate
Yevgeny Berdichevsky, John B. Levine, Marin L. Yarmush
Center for Engineering in Medicine, Massachusetts General Hospital, Harvard Medical School

Microfluidic Cassette for Rapid Isolation of Granulocytes from Whole Blood for Genomic and Proteomic Applications
Kenneth T. Kotz, Aman Russom, Daniel Irimia, Michael Mindrinos, Ronald Davis, Weijun Qian, David Camp, Richard Smith, Lyle L. Moldawer, Ronald G. Tompkins, Mehmet Toner
Massachusetts General Hospital, Boston, MA USA
Stanford University, Stanford, CA USA
University of Florida, Gainesville FL USA
Pacific Northwest National Laboratories, Richland WA USA

Use of Micropatterned Protein Arrays to Create Complex Cellular Interactions
Ji Youn Lee, Sunny Shah, and Alexander Revzin
Department of Biomedical Engineering, University of California, Davis, CA

Single Cell Epitaxy by Acoustic Picoliter Droplets
Grace Montesano, Utkan Demirci
Bio-Acoustic-MEMS in Medicine Laboratory (BAMM), Brigham and Women’s Hospital, Harvard Medical School, Boston, MA

Peptide-Mediated Selective Adhesion of Smooth Muscle Cells and Endothelial Cells in Microfluidic Shear Flow
Brian D. Plouffe, Milica Radisic, Shashi K. Murthy
Department of Chemical Engineering, Northeastern University
Boston, Massachusetts 02115

Isolation of CD61+/CD31+ Phenotype from Peripheral Blood using Microfluidics for Sickle Cell Disease (SCD)
William N. White, Palaniappan Sethu
Department of Bioengineering University of Louisville (502) 852-0350

Nanomagnetic-Microfluidic Separator for Sepsis Control
Chong Wing Yung
Harvard Medical School/Children’s Hospital

Antibody Array-Based MicroCytometry Platform for Capture and Characterization of T-Lymphocytes
He Zhu, Monica Macal, Satya Dandekar, Michael George, Alexander Revzin
Department of Biomedical Engineering, University of California, Davis, CA
Department of Immunology and Microbiology, University of California, Davis, CA

Micropatterned Zinc Oxide Nanoparticle Substrate Preparation and Analysis
Justin T Seil, Diane Hoffman-Kim, Thomas J Webster
Laboratory for Nanomedicine Research, Division of Engineering, Brown University, Providence, RI 02912
Department of Molecular Pharmacology, Physiology and Biotechnology and Center for Biomedical Engineering, Brown University, Providence, RI 02912

Carbon Nanotube-Titanium Electrodes for Detecting Calcium Deposition by Osteoblasts
Sirinrath Sirivisoot, Chang Yao, Xingcheng Xiao, Brian W. Sheldon, Thomas J. Webster
Division of Engineering, Brown University, Providence, RI 02912

Bone-like-Injectable Nanocomposites: Functionalized Helical Rosette Nanotubes and Biocompatibles Hydrogels for Orthopedic Applications
Lijie Zhang, Sharwatie Ramsaywack, Hicham Fenniri, Thomas J. Webster
Division of Engineering, Brown University, Providence, RI, 02912, USA
National Institute for Nanotechnology and Department of Chemistry, University of Alberta, Edmonton, AB, T6G 2M9, CANADA

POLYMERS/BIOMATERIALS

Novel Growth Factor Delivery Techniques for Cartilage Tissue Regeneration from Synovial Progenitor Cells
Bahar Bilgen, Roshni Patel, Ana Jaklenec, Edith Mathiowitz, Michael J. Lysaght, Deborah McK. Ciombor, Roy K. Aaron
Department of Orthopaedics, W. Alpert Medical School of Brown University, RI
Center for Restorative and Regenerative Medicine, Providence VA Medical Center
Center for Biomedical Engineering, Brown University, Providence, RI

In vitro vascularized adipose tissue model
Jennifer Kang, David Kaplan
Tufts University

Silk Fibroin Microtubes for Blood Vessel Engineering
Michael L. Lovett, Christopher Cannizzaro, Laurence Daheron, Brady Messmer, Gordana Vunjak-Novakovic, David L. Kaplan
Department of Biomedical Engineering, Tufts University, 4 Colby St., Medford, MA
Harvard-MIT Division for Health Sciences and Technology, Massachusetts Institute of Technology, 77 Massachusetts Ave., E25-519, Cambridge, MA 02139, USA
Center for Regenerative Medicine, Massachusetts General Hospital, Harvard Medical School, CPZN-Room 4400, 185 Cambridge St., Boston, MA 02114, USA
Harvard Stem Cell Institute, 42 Church St., Cambridge, MA 02138, USA
Department of Biomedical Engineering, Columbia University, 351 Engineering Terrace, 1210 Amsterdam Ave., MC 8904, New York, NY 10027, USA

Method Development for Water Uptake of Polymer Films Using Radiolabeled Water
Loreto Valenzuela, Bozena Michniak, Joachim Kohn
New Jersey Center for Biomaterials, Rutgers, The State University of New Jersey, New Brunswick, NJ 08854-8087

Regulation of Cell Behavior on Silk Fibroin Surfaces by Modification with Polyethylene Glycol
Charu Vepari, Douglas Matheson, Lawrence Drummy, Rajesh Naik, David Kaplan
Departments of Chemical & Biological Engineering, Tufts University, Medford, MA 02155
Materials and Manufacturing Directorate, Air Force Research Laboratory, Wright-Patterson AFB, Dayton, Ohio 45433
Department of Biomedical Engineering, Tufts University, Medford, MA 02155

Sonication Control of Silk Gelation for Cell Delivery Systems
Xiaoqin Wang, Jon Kluge, Gary G. Leisk, P. Grace Chao, Gordana Vunjak-Novakovic, David L. Kaplan
Department of Biomedical Engineering, Tufts University, 4 Colby Street, Medford, MA
Department of Material Engineering, Tufts University, 200 College Ave, Medford, MA
Department of Biomedical Engineering, Columbia University, New York, NY

STEM CELLS

Functional Tissue-Engineered Blood Vessels from Bone Marrow Stem Cells
Jin Yu Liu, Daniel D. Swartz, Hao Fan Peng, Sylvia F. Gugino, James A. Russell, Stelios T. Andreadis
Bioengineering Laboratory, Department of Chemical and Biological Engineering,
Women and Children’s Hospital of Buffalo, Department of Physiology and Biophysics,
University at Buffalo, The State University of New York, Buffalo, NY

Natural Immunotherapeutics Derived From the Bone Marrow Stroma
Biju Parekkadan, Daan van Poll, Kazuhiro Suganuma, Arno W. Tilles, Martin L. Yarmush
Center for Engineering in Medicine, Massachusetts General Hospital, Harvard Medical School, Shriners Hospitals for Children, 51 Blossom Street, Boston, MA 02114 USA
Harvard-MIT Division of Health Sciences and Technology, 77 Massachusetts Avenue, E-25, Cambridge, MA 02138 USA

Engineering a Microenvironment for Embryonic Stem Cell Differentiation into Functional Hepatocytes
Eric YH. Park, Cheul H. Cho, Arno W. Tilles, Martin L. Yarmush.
Center for Engineering in Medicine; Dept. of Surgical Research; Mass General Hospital; Harvard School of Medicine; Shriners Hospitals for Children, Boston, MA

Role of Membrane Potential in Osteogenic and Adipogenic Differentiation of Human Mesenchymal Stem Cells
Sarah Sundelacruz, Michael Levin, David L. Kaplan
Tufts University

Gene Delivery to Differentiating Stem Cells for Recovery and Functional Enrichment of Hepatocyte-Like Cells
Eric J. Wallenstein, Rene S. Schloss, Martin L. Yarmush,
Department of Biomedical Engineering, Rutgers University, Piscataway, NJ 08854

Expression of Neural and Cardiomyogenic Lineage Markers by Mesenchymal Stem Cells from Human Bone Marrow and Wharton’s Jelly
Deniz Yucel, Halime Kenar, Palaniappan Sethu, Natesh Parashurama, Vasif Hasirci, David Kaplan, Mehmet Toner
Middle East Technical University, Faculty of Arts and Sciences, Department of Biological Sciences, Biotechnology Research Unit, Ankara 06531, Turkey,
Surgical Services and Center for Engineering in Medicine, Massachusetts General Hospital, Harvard Medical School and Shriners Hospital for Children, Boston, MA 02114, USA,
Tufts University , Department of Biomedical Engineering, Bioengineering & Biotechnology Center, 4 Colby Street, Medford, MA 02155, USA