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Methods in Bioengineering 2006 - Posters



BIOMECHANICAL TESTING


Mechanical Properties of Tissue-Engineered Media, Adventitia and Blood Vessels Reconstructed In Vitro by the Self-Assembly Approach
Robert Gauvin, Danielle Larouche, Taby Ahsan, Jule Guérard, Jean-François Oligny, François A. Auger, Robert M. Nerem, Lucie Germain
LOEX, Hopital du Saint-Sacrement, Quebec

A Bioreactor for Mechano-Stimulation and Material Evaluation in Functional Tissue Engineering
Mark Sommers, Daniel Haberstroh, Massimo Kubon, Michael Bottlang
Biomechanics Laboratory, Legacy Research and Technology Center, Portland, OR

Design of a New Experimental Setup for the Measurement of Burst Pressure and Compliance of Tissue Engineered Blood Vessels
Philippe Lévesque, Robert Gauvin, Julie Guérard, Jean-François Oligny, Danielle Larouche, Lucie Germain, François A. Auger
LOEX, Hopital du Saint-Sacrement, Quebec

Biodynamic Test Instrument for Characterization of Tissues and Biomaterials

Sandy Williams, Tom Fotiades, Troy Nickel, and Lito Mejia
ElectroForce Systems Group, Bose Corporation, Eden Prairie, MN, USA

ECM/SCAFFOLDS


Designing Tissue Scaffolds that Direct Keratinocyte Function: A Multi-Scale Approach
Katie A. Bush, B.R. Downing, E. Soto, W.G. McGimpsey, M. Toner, and G.D. Pins
Worcester Polytechnic Institute, Biomedical Engineering

Collagen Implants for Spinal Cord Regeneration
Rahmat Cholas, C. Ma, H. Hsu, I. Yannas and M. Spector
MIT, Mechanical Engineering

Collagen and Fibrin Microthreads in a Descrete Thread Model of In Vitro ACL Scaffold Regeneration
Kevin G. Cornwell and George D. Pins
WPI/UMass Medical School, Biomedical Engineering

Carbon Nanotubes as a Potential Scaffold Material for Stem Cell Differentiation In Vitro
Batur Ercan and Thomas Webster
Brown University, Engineering Department

Harnessing Proteoglycans and Glycosaminoglycans in Tissue Engineering

Jane Grande-Allen, Vishal Gupta, Zannatul Ferdous and David Allison
Rice University, Department of Engineering

Mold-Shaped Nanofiber-Based Cartilage Engineering in a Bioreactor for Nasal Reconstructive Surgery
Sasa Janjanin, Wan-Ju Li, Rabie M. Shanti and Rocky Tuan
NIH, Cartilage Biology and Orthopaedics Branch

Optimized Method to Enhance Stem Cell Adhesion in a 3-D Collagen and PEGDA Scaffold
Arpita Kadakia
University of Illinois, Department of Bio Engineering

Quantitative Biorelevant Profiling of Material Microstructure within 3D Porous Scaffolds via Multiphoton Fluorescence Microscopy
Er Liu, Patrich Johnson, Parth Patel, Danielle Macario, Gary B. Nackman, Joachim Kohn and Prabhas V. Moghe
Rutgers University, Department of Biomedical Engineering

Protein Pre-Coating of Elastomeric Tissue-Engineering Scaffolds: Extracellular Matrix Formation and Phenotypic Changes of Circulating Endothelial Progenitor Cells
Virna Sales, George C. Engelmayr, Jr., Danielle Gottlieb, John A. Johnson, Jr., Jin Gao, Yadong Wang, Michael S. Sacks, John E. Mayer, Jr.
Children's Hospital, Boston, Harvard Medical School, Department of Cardiovascular Surgery

A Synthetic Biocompatible Nanofibrous Scaffold for Adipose Tissue Engineering
Rabie M. Shanti, Sasa Janjanin, Wan-Ju Li, Leon J. Nesti, Michael B. Mueller, Megan B. Tzeng, Yi Jen Jiang and Rocky S. Tuan
NIH, Cartilage Giology and Orthopaedics Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases

Immobilized Protein Gradients for Tissue Engineering
Charu Vepari, Gordana Vunjak-Novakovic and David Kaplan
Tufts University, Departments of Chemical and Biological Engineering and Biomedical Engineering

Development of a Cell-Seeded Collagen-Glycosaminoglycan Implant for Articular Cartilage Regeneration
Scott M. Vickers and Myron Spector
MIT, Mechanical Engineering



GENE DELIVERY


Enzyme/DNA/Inorganic Materials: Enhancing the Structure, Activity and Stability of Proteins by DNA
Akhilesh Bhambhani and Chalia V. Kumar
University of Connecticut, Department of Chemistry

Molecular Design and Cellular Delivery of Oligonucleotides
Charles Roth
Rutgers University, Biomedical Engineering

Differentially-Expressed Genes Conferring Increased Lycopene Production
Brian Mickus and Charles Cooney
MIT, Department of Chemical Engineering



MICROFABRICATION


A Polymeric Micro/Nanostructuring Method for Biomedical Applications
Chao-Min Cheng and Philip R. LeDuc
Carnegie Mellon University, Departments of Mechanical and Biomedical Engineering, and Biological Sciences

CD4 T-lymphocyte Counting Microfluidic Chip for HIV Diagnosis in Global Health
Utkan Demirci, M. Dixon, D. Irimia, X. Cheng, L. Zamir, W. Rodriguez, M. Toner
Harvard Medical School, BioMEMS Resource Center, Center for Engineering in Medicine, Massachusetts General Hospital

Versatile Microfluidic Device for Long-Term Culture of Mammalian Cells
Rafael Gómez-Sjöberg, Anne Leyrat, Stephen Quake
Stanford University, Department of Bioengineering

Development of a Platform for the Monitoring of Extracellular Ionic Activities
O.T. Guenat, S. Generelli, N.F. de Rooij, M. Koudelka-Hep, F. Berthiaume,
M.L. Yarmush
Center for Engineering in Medicine, MGH, HMS
SAMLAB, Institute of Microtechnology, University of Neuchâtel, Switzerland


Microarray Biochips for High-Throughput Drug Screening
Moo-Yeal Lee, R. Anand Kumar, Douglas S. Clark and Jonathan S. Dordick
Solidus Biosciences, Inc., Troy, NY
Chemical and Biological Engineering, Rensselaer Polytechnic Institute, Troy, NY Chemical Engineering, University of California at Berkeley, Berkeley, CA

A Microdevice for Retrovirus Production 
Yawen Li, Monica Casali, Daniel Irimia, Zak Megeed, Martin Yarmush
Center for Engineering in Medicine, MGH, Harvard Medical School

In Vitro Evaluation of Microfabricated Silicon Nanoporous Membranes for Therapeutic Applications of Neurosecretory Cells
Carlos A. Lopez, B. K. Yamamoto, T. A. Desai
Biomedical Engineering, Boston University, Boston, MA 
Pharmacology and Experimental Therapeutics, Boston University School of Medicine
Physiology and Division of Bioengineering, University of California San Francisco

An integrated microfluidic electrochemical sensor array with a VLSI potentiostat 
Kartikeya Murari, A. Rege, M. Naware, M. Stanacevic, M. Paranjape,G. Cauwenberghs and N. Thakor
Biomedical Engineering, Johns Hopkins University
Electrical and Computer Eng., State University of New York, Stony Brook
Physics, Georgetown University
Neurobiology, University of California, San Diego

Microfabricated Composite Scaffolds for Controlling Cellular Organization and Proliferation in Three-Dimensional Tissue Constructs
James J. Norman, Sadhana Sharma, John M. Collins, Brenda Russel, Tejal A. Desai
Biomedical Engineering, Boston University.
Physiology and Biophysics. University of Illinois at Chicago
Physiology and Division of Bioengineering, University of California, San Francisco

Stacked Radial Flow Bioartificial Liver Device using MIcrofabricated Grooved Substrates
Jaesung Park, François Berthiaume, Mehmet Toner, Martin L. Yarmush, Arno W. Tilles
Center for Engineering in Medicine, Massachusetts General Hospital and Shriners Burns Hospitals, Harvard Medical School, Boston, MA

Analysis of Local Liver-Specific Gene Expression in Hepatocellular Micropatterns
Ji Youn Lee, Caroline Jones, Mark Zern and Alexander Revzin
Department of Biomedical Engineering, University of California, Davis

Effect of Cell Culture Substrate Topology on Caco-2 Cell Growth and Attachment 
Lin Wang, Shashi Murthy, Rebecca L. Carrier
Department of Chemical Engineering, Northeastern University, Boston, MA



NANOTECHNOLOGY

Magnetic Nanoparticles for the Treatment of Osteoporosis
Ganesan Balasundaram and T.J. Webster
Brown University, Division of Engineering

Nanophase Titania/PLGA (Poly-Lactide-co-Glycolide) Composites for Bone Tissue Engineering Applications
Huinan Liu and Thomas J. Webster
Brown University, Division of Engineering

Endothelial Cell Adhesion On Highly Controllable Nanostructured Titanium Surface Features for Improved Vascular Stent Applications
Jing Lu
Brown University, Division of Engineering

Synthesis and Processing of Surfactant-Free, Drug-Loaded Nanoparticles for Antioxidant Therapy
Barrett J. Nehilla and Tejal A. Desai
Boston University, Departments of Biomedical Engineering and Pharmacology & Experimental Therapeutics

Developing Biosensors for Monitoring Orthopedic Tissue Growth 
Sirinrath Sirivisoot, Chang Yao, Xingcheng Xiao, Brian Sheldon,
and Thomas J. Webster
Brown University, Division of Engineering

Increased Osteoblast Adhesion on Nano-Rough Anodized Titanium and CoCrMo Chang Yao, Elliott B. Slamovich, and Thomas J. Webster
Brown University, Division of Engineering

Helical Rosette Nanotubes for Orthopaedic Applications
Lijie Zhang, Ai Lin Chun2, Hicham Fenniri and Thomas Webster
Brown University, Division of Engineering and Orthopaedics



POLYMERS/BIOMATERIALS

Layer-by-Layer Polymer Thin Films for Sequential Delivery of Multiple Drugs 
Helen F. Chuang and Paula T. Hammond
Massachusetts Institute of Technology, Department of Chemical Engineering

Expanded PTFE Vascular Grafts with Nitric Oxide (NO)-Generating Cu(II)-Complex Polymer Coatings: A Potential Approach to Improved Thromboresistivity and Reduced Neointimal Hyperplasia
Megan C. Frost, Yang Wang, Jiunhua Zhang, Maheshkumaar Krishnamoorthy ,
Sang-yeul Hwang, Prabir Roy-Chaudhury, Mark E. Meyerhoff
Department of Chemistry, University of Michigan, Ann Arbor, MI
Department of Medicine, University of Cincinnati, Cincinnati, OH

Mathematical Model Based on Queueing Theory to Predict the Controlled Diffusion in Alginate/PEG hydrogels 
Siddharth Gadkari, Nadarajan Sundar Babu, Leonard Stephansky, Elisabeth Papazoglou
Drexel University, Biomedical Engineering, Science & Health Systems

Nitric Oxide Generating Materials Based on Immobilized Catalysts for Nitrosothiol Decomposition in Blood:  A Novel Approach for Creating Thromboresistant Polymers 
Sangyeul Hwang, Wansik Cha, Mustafa Musameh, Hyoung-Sik Yim, and Mark E. Meyerhoff
Department of Chemistry, The University of Michigan, Ann Arbor, MI

PEG and Iodine Within Polycarbonates Antagonistically Affect Protein Adsorption
Danielle Macario, Entersz. I., Kohn, J., Nackman, G.
University of Medicine and Dentistry of New Jersey, New Brunswick, NJ
Rutgers University, Piscataway, NJ

Design of Heparinized Carbon Nanotubes Carrier-Enhanced Blood Compatibility Using Covalent Chemistry
Tae-Joon Park, Saravanababu Murugesan, Jin Xue, Shaker Mousa and Robert J. Linhardt
Department of Chemical and Biological Engineering, Chemistry and Chemical Biology , and Biology, Rensselaer Polytechnic Institute
Pharmaceutical Research Institute, Albany College of Pharmacy

Fluororeporter-Based Cell Profiling on Biomaterials: Technologies for Building A Cell-Biomaterial Interactome
Matthew D. Treiser, Patrick Johnson, Dewang Patel, Robert A. Dubin, Joachim Kohn and Prabhas Moghe
Department of Biomedical Engineering, Department of Chemical and Biochemical Engineering, Department of Chemistry and Chemical Biology, The New Jersey Center for Biomaterials, Rutgers University, Piscataway, NJ

A Dual-Acting Biomimetic Polymeric Coating — Combining Nitric Oxide Release with Surface-Bound Active Thrombomodulin
Biyun Wu, Zhengrong Zhou and Mark E. Meyerhoff *
Department of Chemistry, The University of Michigan Ann Arbor, MI
*BioSurfaces, Ashland, MA

Immobilization of Recombinant Human-Activated Protein C to Dacron: Creation of a Novel Anti-Coagulant Surface 
Sheng-Qian Wu, Matthew D. Phaneuf and Frank W. LoGerfo
Department of Vascular Surgery, BIDMC/Harvard Medical School,

Improving Blood Compatibility at Polymer/Blood Interface via In Situ Generation of Nitric Oxide
Yiduo Wu, Mark E. Meyerhoff
Department of Chemistry, the University of Michigan, Ann Arbor, MI



STEM CELLS

Embryonic Stem Cell Differentiation into Early Endodermal and Hepatic Lineage CellsCheul H. Cho, Natesh Parashurama, Arno W. Tilles, Francois Berthiaume,
and Martin L. Yarmush
Center for Engineering in Medicine, Massachusetts General Hospital, and Shriners Burns Hospital, Harvard Medical School, Boston, MA

Engineering of Implantable Tissue-Engineered Blood Vessels from Bone Marrow Stem Cells 
Jin Yu Liu, Lan Yao, Daniel D. Swartz and Stelios T. Andreadis
Bioengineering Laboratory, Department of Biological and Chemical Engineering,
State University of New York at Buffalo, NY


Synergistic Enhancement of BMP-4 and TGF-β3 on Chondrogenic Differentiation of Human Mesenchymal Stem Cells 
Meredith T. Morgan and Rocky S. Tuan
Cartilage Biology and Orthopaedics Branch, National Institute of Arthritis,
Musculoskeletal & Skin Diseases, National Institutes of Health, Department of Health and Human Services, Bethesda, MD

Immunoprotective Effect of Bone Marrow Stromal-Derived Paracrine Factors in Acute Liver Injury
Daan van Poll , Biju Parekkadan, Kazuhiro Suganuma, Zak Megeed, Arno W. Tilles, François Berthiaume, and Martin L. Yarmush
Center for Engineering in Medicine, BioMEMS Resource Center, Massachusetts General Hospital, Shriners Burns Hospital, Harvard Medical School, Boston, MA



WOUND HEALING


Distinct C/EBP Isoforms Mediate Integrin Expression and Proliferation of Epidermal Keratinocytes and Bioengineered Skin Substitutes 
Piyush Koria and Stelios T. Andreadis
Bioengineering Laboratory, Department of Biological and Chemical Engineering, State University of New York at Buffalo, NY

Mechanical Cues from the Microenvironment Impact Signals Propagated from FN-α5β1 Interactions and TGFβ, Governing Fibroblast Contractile Function
Teerin T. Meckmongkol, R. Harmon, and L. Van De Water
Albany Medical College

In Vitro Studies of Selective Targeting of Pigmented Retinal Pigment Epithelium (RPE) Cells and Accompanying Bio-Stimulation Effects
Qing Song, Rmaon Risco, Mark Latina, Francois Berthiaume, Martin Yarmush
Center of Engineering in Medicine, MGH,  Harvard Medical School




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